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Supersaturated Calcium Phosphate for Prevention and Treatment of Oral Mucositis

Oral mucositis (OM) is a common complication and one of the greatest treatment-limiting toxicities associated with chemotherapy or radiation therapy to the head and neck. Cell death results in inflammation and painful ulcerations. The epithelial lining of the entire gastrointestinal tract is highly susceptible to mucositis due to rapid cell turnover.

About 40% of patients receiving standard chemotherapy, up to 75% of patients receiving an allogeneic hematopoietic stem cell transplant (HSCT), and almost all patients receiving radiation therapy to the head and neck region will experience complications with OM to some degree. This can result in pain and challenges with eating, drinking, oral hygiene and speaking. More severe cases can delay or interrupt treatment, require PEG tube placement for nutritional support, increase cost and hospitalization. There are also significant risks of infection and even death.

The following chart is a grading system demonstrating levels of OM by both the World Health Organization (WHO) and the National Cancer Institute (NCI).

There is evidence that using a Supersaturated Calcium Phosphate mouth rinse can reduce the grade, duration and pain associated with OM. This can result in parallel reductions in all of the associated complications including costs involved with extended hospitalization and PEG tube placement, while increasing positive treatment outcomes.

According to the study, Treating oral mucositis with a supersaturated calcium phosphate rinse: comparison with control in patients undergoing allogeneic hematopoietic stem cell transplantation, there are distinguishing features of SCPR in comparison with other mouth rinses,
including:
· In theory, the high concentrations of Ca2+ and PO43− ions diffuse into intercellular spaces of the epithelium and penetrate mucosal lesions.

· Ca2+ ions play an essential role in inflammation, blood-clotting, fibrin production and tissue repair.

· PO43- ions promote intercellular signaling and regulating the voltage potential inside of cells, helping to protect and repair injured mucosal tissue.

· Raising the pH of the xerostomic oral cavity, helping to avoid mucosal injury and providing a more hospitable environment to favorable organisms.

SalivaMAX® is an FDA approved supersaturated calcium phosphate rinse now available by prescription. It is indicated for oral mucositis, xerostomia and hyposalivation. You can download your prescription HERE or request a personalized prescription pad for your office by contacting us at jill@sideeffectsupport.com.

References and photo credits:

NCCN Task Force Report: Prevention and Management of Mucositis in Cancer Care

SalivaMAX Research

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